Diarrhea: ~12% (2% were severe, and 2% of patients discontinued treatment due to diarrhea).No patients in the clinical studies were hospitalized due to nausea.) The rate of nausea was lower among male (8%) and elderly (19%) patients. Nausea ~ 29% (4% were severe, and 9% of patients discontinued treatment due to nausea.Other adverse events (≥5% of patients) included diarrhea (13%), headache (13%), abdominal distension (5%), abdominal pain (5%), flatulence (6%), sinusitis (5%), vomiting (5%), and fecal incontinence (1%).įor subjects with chronic idiopathic constipation taking Amitiza:
In clinical trials, the most common adverse event was nausea (31%). If one misses a dose it should be taken as soon as possible unless it is almost time for the next dose, in which case it should be skipped and the user should return to their regular dosing schedule. It comes in a liquid filled capsule and is available only with a doctor's prescription. There is current research under way to determine the safety and efficacy in postoperative bowel dysfunction. Lubiprostone has not been studied in children. Irritable bowel syndrome with constipation (IBS-C a condition that causes stomach pain or cramps, bloating, and infrequent or difficult passage of stools) in women who are at least 18 years of age.The effectiveness of lubiprostone has not been established in patients who are taking a diphenylheptane opioid (e.g., methadone).Constipation caused by certain opioid (narcotic) pain medications in people with chronic (on-going), noncancer pain, or in patients with long-lasting pain caused by a previous cancer or its treatment who do not need weekly increases in opioid dosage.Chronic idiopathic constipation (difficult or infrequent passage of stools that lasts for 3 months or longer and is not caused by diet, disease, or drugs).Lubiprostone is a laxative used for the treatment of constipation, specifically: In Bangladesh and India, lubiprostone is marketed under the trade name Lubigut by Ziska Pharmaceuticals, Lubilax by Beacon Pharmaceuticals, and under the trade name Lubowel by Sun Pharmaceutical. The drug is available in the United States, Japan, Switzerland, India, Bangladesh, United Kingdom, and Canada. It is available through prescription only. Lubiprostone received approval from the Food and Drug Administration in 2008 to treat irritable bowel syndrome with constipation (IBS-C), and in 2013 for the treatment of OIC in adults with chronic noncancer pain. The cost to the NHS was £29.68 per 24 mcg 28-cap pack as of April 2017. It was recommended for use in the UK by the National Institute for Health and Care Excellence (NICE) in July 2014. The drug was developed by Sucampo Pharmaceuticals and approved by the Food and Drug Administration (FDA) in 2006. The drug is owned by Mallinckrodt and is marketed by Takeda Pharmaceutical Company. Lubiprostone ( rINN, marketed under the trade name Amitiza among others) is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation.
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